Research Associate - LCMS - Contract- San Diego, California
Proclinical is seeking an enthusiastic and highly-skilled Research Associate - LCMS to join the Bio-analysis team at an exciting biotech in San Diego.
Primary Responsibilities:
The successful candidate will be supporting the progression of our therapeutic programs by conducting bioanalysis of small molecules, antisense oligonucleotides (ASOs), and proteins for preclinical PK and PK/pharmacodynamic (PD) studies. This role demands a solid understanding of analytical principles, hands-on experience with targeted liquid chromatography (LC)-mass spectrometry (MS), and familiarity with DMPK fundamentals.
Skills & Requirements:
- Holds a Bachelor's or Master's degree in Chemistry, Biology, Pharmaceutical Sciences, or related field and 1-3 years of experience in bioanalysis.
- Possesses direct hands-on experience with bioanalysis and absolute quantitation with LC-MS and can perform basic method troubleshooting and optimization.
- Has a firm understanding of analytical principles and can use figures of merit to evaluate data quality.
- Provides clear and timely communication for effective collaboration with cross-functional teams.
- Has exceptional organizational skills, attention to detail, time management, and the ability to work both independently and as part of a team.
- Willing to learn new techniques as needed to help support the team.
The Research Associate - LCMS's responsibilities will be:
- Conduct bioanalysis of drugs, metabolites, and PD markers in complex biological matrices such as biofluids, tissues, and cells.
- Perform absolute quantitation on a triple quadrupole LC-MS system and calculations for non-compartmental analysis (NCA).
- Collaborate with DMPK and pharmacology leads on timeline planning, study prep, and experimental logistics.
- Collect and record experimental data in an electronic lab notebook, ensuring meticulous documentation, data integrity, traceability, and regulatory compliance; produce readable and functional reports for PK data.
- Contribute to the development and optimization of experimental techniques and protocols to ensure we deliver high-quality data for decision-making.
- Monitor consumable inventory and provide basic troubleshooting, maintenance, and performance benchmarking for DMPK LC-MS systems.
- Collaborate with cross-functional teams, including Institute of Sciences, In Vitro/Vivo Pharmacology, Science Integration, Innovation and Insights, and more to support the development and progression of therapeutic programs.
- Foster a team culture of continuous improvement, ownership, professional growth, and inclusion.
Preferred Qualifications:
- Experience performing bioanalysis on small molecules and proteins is desirable; experience performing bioanalysis on ASOs is highly desirable.
- Knowledge and experience using R-Studio, or similar platforms, for data analysis is desirable.
If you are having difficulty in applying or if you have any questions, please contact Alexander Bero at a.bero@proclinical.com
Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.
Proclinical Staffing is an equal opportunity employer.
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