Director of Preclinical Development, siRNA - Perm - Boston, MA
Proclinical is on the lookout for a dynamic and innovative individual to fill the role of Director, Preclinical Development. This role presents a unique opportunity to lead our Preclinical Development team, overseeing the design and execution of preclinical projects for RNAi therapeutic programs.
Primary Responsibilities:
The successful candidate will play a crucial role in our mission to integrate cutting-edge computation and AI with RNAi to develop transformative medicines.
Skills & Requirements:
- A PhD in biology, pharmacology or a related discipline, with a deep insight into how in vivo systems translate to human disease.
- Extensive experience in drug discovery with a track record of using pre-clinical models to evaluate new drug candidates and mechanism of action.
- Knowledge of the CRO landscape and experience working with preclinical CROs to deliver fully costed agreements and study protocols.
- A commitment to generating data of the highest integrity, complying with regulatory requirements and ethical standards.
- Strong project management, organisational and leadership skills.
- Excellent communication skills in verbal and written English.
- Experience with IND-enabling activities and the preparation of regulatory packages (preferred).
- A background in therapeutic siRNA or other oligonucleotide therapeutics (preferred).
The Director of Preclinical Development, siRNA's responsibilities will be:
- Lead cross-functional project teams to execute an in vivo strategy that ensures efficient and effective project decision-making.
- Ensure all preclinical programs are designed with clear go/no go gates and are completed within established timelines.
- Prepare and present preclinical project updates to the Executive Team.
- Collaborate closely with project management, finance, and operations teams.
- Manage and progress work with a network of trusted partner CROs to generate data that supports candidate selection and regulatory requirements.
- Serve as the subject matter expert in the indications and disease areas being pursued, developing and maintaining an excellent knowledge of the treatment landscape and early- and late-stage competitor pipelines.
- Develop TPPs, ensuring that the critical biological readouts / key differentiators are addressed; and periodically revising in response to internal data generation and ongoing landscape evaluation.
If you are having difficulty in applying or if you have any questions, please contact Max Robinson at m.robinson@proclinical.com
Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.
Proclinical Staffing is an equal opportunity employer.
