Scientist/Senior Scientist, Functional Genomics

Proclinical is seeking a Scientist/Senior Scientist, Functional Genomics for a cutting-edge biotechnology company located in South San Francisco, CA.

As a Functional Genomics Scientist/Senior Scientist, you will advance the company's platform for the identification and validation of functional RNA targets for drug discovery.

Must be eligible to work in the US.

Job Responsibilities:

• Identify and validate domains in human mRNAs that regulate cellular function including processing, splicing, translation, or stability.
• Design, execute, and troubleshoot NGS-based experiments to understand the sequence determinants of RNA regulatory domains.
• Recruit, mentor, and oversee research associates.
• Analyze, interpret, and organize data, and clearly document and communicate research outcomes to colleagues.
• Work within a collaborative, high-caliber, interdisciplinary team.

Skills and Requirements:

• Ph.D. in Genetics, Biology, Biochemistry, Bioengineering, or related field.
• Deep understanding of mammalian RNA regulation mechanisms.
• Experience developing, validating, and applying MPRA or minigene reporter assays for pooled or arrayed screening of RNA function in mammalian cells.
• Experience decoding RNA regulation using NGS-based methods, such as RNA-seq, polysome profiling, ribosome footprinting, metabolic labeling, eCLIP, or CRISPR screening.
• Proficient in data analysis using Python (or similar language) and common bioinformatics tools.
• Mature in scientific thinking and rigorous in recording methodologies and results.
• Excellent presentation and writing skills, able to clearly communicate technical information to colleagues.
• Ability to plan and execute in a fast-paced environment and agility to adapt to changing priorities.
• Excellent presentation and writing skills, ability to clearly communicate technical information to colleagues.
• 3+ years of relevant industry or post-doctoral research experience.
• Familiar with experimental and computational techniques used to measure, model, and analyze RNA structure.
• Familiar with concepts and methods in early drug discovery

If you are having difficulty in applying or if you have any questions, please contact Danielle Bahnasy at +(1) 646-868-5142 or d.bahnasy@proclinical.com.

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.

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